Lots of xtal solving packages has been developed. Many different algorithms can suitable for all kinds of protein crystals.
I neaten some of importance here and share my experience.
<1>. phasing solving:
CCP4(about hundreds of crystal software are here. You can do almost in it from data processing to model drawing, GUI )
SOLVE/RESOLVE( the most popular phase solving software by heavy atom, like Se, Hg and so on, easy to use, command line)
SHARP(maximium likely hood algorithm to refine heavy atom and phasing but more suitable for good resolution data, web interface and CCP4 needed)
SHELX(SHELX for macromolecules, especially the location of heavy atoms from MAD, SIR and SAD data, command line)
Phaser(fast and easy software for molecular replacement, command line or GUI in CCP4)
PHENIX(automated X-ray crystal software to determine the strucutre, combined SOLVE/RESOLVE, Phaser, TEXTAL, Hyss and PyMoL, highly recommanded tool for Xray strucutre solving, GUI)
<2>. model building
ARP/wARP(automatic model building tool but need good resolution data, GUI in CCP4)
TEXTAL(automatic model building especially backbone building and suitable for low resolution data)
O(model building with manually)
XtalView(good, common model building tool)
model draw
............to be continuned
